Donnie Yance is an internationally known master herbalist and nutritionist. He is the author of the book, "Herbal Medicine, Healing and Cancer" and "Adaptogens in Medical Herbalism"
Vaccines No Match for Omicron and a Look at COVID-19 in Africa
We’ve been living with COVID-19 now for more than two years, and questions continue to
arise about the best approach for prevention and treatment. I have never been asked about anything as much as the COVID-19 vaccines and never have I seen so much doubt and confusion among so many people. The emergence of the Omicron variant has made the issue more confusing and raises more questions about the efficacy of vaccines against COVID-19. Interpreting the reality of the effectiveness of these vaccines is complicated, especially when some of the new data is not robust and is often murky. Patients and doctors looking to the CDC for guidance in decision-making receive low-quality or outdated information. All too often, straightforward relative data – such as the benefits of normalizing vitamin D and zinc levels – is ignored. Please see my earlier blogs on Zinc and Vitamin D for more information here “Zinc the Most Important Nutrient for Immunity” and “There’s No Substitute for Sunlight: The Essential Influence of Nature’s Sunshine Vitamin on Health“
During this Christmas season, as I meditate on the image of the innocent, vulnerable baby Jesus, I am reminded of the opportunity for spiritual renewal. I think most of us can relate on some level, even those who do not identify themselves as Christians. Perhaps it is simply the idea of birth and a chance to begin again that calls to us, that gives us hope as this year comes to a close and a New Year beckons.
At the surface there is really nothing glamorous about Christmas. Do you ever wonder what courage, trust and faith Mary and Joseph had? We have Joseph breaking the law, knowing what he should do with a seemingly “adulterous woman,” but he doesn’t divorce Mary as the Law clearly tells him to do, even though he has no direct way of knowing that the baby was conceived by the Holy Spirit [Matthew 1:18–24].[1] Think about the fact that they were homeless – born in a stable surrounded by unknown Shepherds and animals. What is the meaning of all this? And what does this have to do with me?
Inspired by the purity of the baby Jesus, I reflect on the scripture from Matthew 18:3, where Jesus says, “Truly I tell you, unless you change and become like little children, you will never enter the kingdom of heaven.”
Of course, as we mature, we must take on the responsibilities of adulthood. But all too often, along the way we become focused solely on worldly life. Our behavior and our choices are influenced by the people who are most important to us. In the past, it was parents, friends, and teachers. Today, we have a great many more connections through social media and the internet. These influences mold us into who we are. Along the way, we are prone to losing our innocence, and if we are not aware, we can also lose our potential for divinity.
The biblical creation story in the Torah (Old Testament) states, “Let us make humans in our image” (Genesis 1:26). The plural pronoun is the first hint that we are going to be brought into a relational, participatory, and shared life. The secret is planted within our deepest identity and slowly reveals itself. Then, for the most part, we turn away until our life as we know it comes close to the end.[2]
Father Richard Rohr views religion’s purpose as reminding us of who we truly are: “The essential work of religion is to help us recognize and recover the divine image in ourselves and everything else too. Whatever we call it, this ‘image of God’ is absolute and unchanging. There is nothing we can do to increase or decrease it. It is not ours to decide who has it or does not have it. It is a pure and total gift, given equally to all.”[3]
Contemplation Leads Us to Truth
Contemplation teaches us how to observe our own small mind and, frankly, to see how inadequate it is to the task in front of us. As Eckhart Tolle says, 98% of human thought is “repetitive and pointless.”
“Why do you look to one another for approval instead of the approval that comes from the one God?” (John 5:44). So many of us accept our self-image from within a system of false images. Whether we describe ourselves as smart, strong, good looking, or a loser—all are just words created by humans. This will never work. We must find our true self hidden within—that Divine image we are made in. St. Teresa of Ávila envisioned God telling her, “If you wish to find Me, in yourself seek Me.”[4]
The one who is spirit took on flesh for all eternity. As C.S. Lewis says in Mere Christianity, “It is really, I suggest, a timeless truth about God, that human nature, and the human experience of weakness and sleep and ignorance, are somehow included in his whole divine life.” Jesus had to be made like us in every way (Hebrews 2:17). His body is not insignificant.
Transformation through Love
So, I ask the question, “Why? And what does this have to do with me?” We all have some kind of image of God, but how do we know these are not false images? I believe we cannot begin to find the answer until we are willing to be reached by an all-transforming movement of love. This is based in trust, to be willing to let go and let be. As Meister Eckhart says, “For the person who has learned to let go and let be, nothing can ever get in the way again.”
Whether you are Christian or not, we can start with an image of the baby Jesus, the ultimate expression of God’s humility, and let go of all the garbage we carry. Christmas to me is a reminder that God became human so that we may become Divine. Our DNA is divine, and the divine indwelling is never earned by any behavior, group membership, ritual, or hiding from it (“Hiding from God” Genesis 3:8, “How did you know you were naked?” Genesis 3:11). When we don’t see ourselves as Divine, we can easily instead experience nakedness, vulnerability, guilt, shame, and rebellion. We must rise above, recognize, and realize (see Romans 11:6; Ephesians 2:8–10) and thus fall in love with the God within and share it.[5]
Our Lady of Vladimir: The Virgin of Tenderness
Our Lady of Vladimir, my personal favorite icon, also known as Vladimir Mother of God, and the Theotokos of Vladimir, is a 12th-century Byzantine icon depicting the Virgin and Child.
Icons are images of a sacred person or scene used in the Eastern churches of the Christian world. True icons are the culmination of a long period of prayer, meditation, and fasting undertaken by the artist. In this way, the artist is brought close in spirit to God. Thus, icons are often called “a meeting of heaven and earth” or “windows into heaven.”[6]
This icon, depicting the Virgin Mary with the infant Christ nestled against her cheek, is also known as “The Virgin of Tenderness.”[7] From antiquity, Mary has been called “Theotokos” or “God-Bearer” (Mother of God). The Theotokos is the most elevated human being in the Eastern and Western church. She is the ultimate example of the human capacity to surrender, trusting in God and following that trust.[8]
May each of us begin again and truly live, believing that we are made in the image of God. Let us manifest selfless love, let us be the Light in the world, and with joy in our hearts, let us be of service to others. Let us truly reflect the birth of Christ in our souls. This Divine heart within is a spiritual portrait of the heart of the universe: strongly aglow with the divine fire, beaming light in every direction, and at the same time open because it is wounded.[9]
Wishing a Joyous Christmas, Winter Solstice, belated Chanukah, and a Happy New Year to you all and our world. May our prayers be our words in deeds, and may our earth be made very peaceful because of each of us.
[4] Teresa, “Seeking God,” in The Collected Works of St. Teresa of Avila, vol. 3, trans. Kieran Kavanaugh and Otilio Rodriguez (ICS Publications: 1985), 385.
Although Omicron is now 73% of all new cases in the US[1], I don’t feel we need to press the panic button. I have some hypotheses on the emergence of the Omicron variant that could put the brakes on the doom and gloom scenario we are all being fed.
Photo from the Hollywood Mirror
According to a study published on December 16th, authored by more than 20 scientists at Columbia and the University of Hong Kong, a striking feature of the Omicron variant is the large number of spike mutations that pose a threat to the efficacy of current COVID-19 vaccines, vaccine boosters and antibody therapies.[2] The scientists express concern that the variant’s “extensive” mutations can “greatly compromise” the vaccine, even neutralizing it. The report said the booster shots prevent some of the neutralization, but the variant “may still pose a risk” for those with their third shot. “Even a third booster shot may not adequately protect against Omicron infection,” the study said.
Omicron is spreading faster than previous variants of the novel coronavirus with the virus now in at least 90 countries since it first appeared in South Africa last month. Therefore, the Omicron variant could “out compete” other variants, including the more dangerous Delta variant – thus becoming the dominant variant. However, Omicron infections seem to be less severe and hospitalization and death nowhere near the rates of the other variants. Early reports suggest South Africa were reporting that people testing positive are presenting with mild symptoms: “In fact, they said, most of their infected patients were admitted for other reasons and have no Covid symptoms.” In other words, most of these patients had evidence of infection with SARS-CoV-2 but did not have COVID-19.[3]
What about Africa and Omicron?
There is something “mysterious” going on in Africa that is puzzling scientists, said Wafaa El-Sadr, chair of global health at Columbia University. “Africa doesn’t have the vaccines and the resources to fight COVID-19 that they have in Europe and the U.S., but somehow they seem to be doing better,” she said. Fewer than 6% of people in Africa are vaccinated.
“I think there’s a different cultural approach in Africa, where these countries have approached COVID-19 with a sense of humility because they’ve experienced things like Ebola, polio and malaria,” Sridhar said.
In past months, the coronavirus has pummeled South Africa and is estimated to have killed more than 89,000 people there, by far the most deaths on the continent. But for now, African authorities, while acknowledging that there could be gaps, are not reporting huge numbers of unexpected fatalities that might be COVID-19 related. WHO data shows that deaths in Africa make up just 3% of the global total. In comparison, deaths in the Americas and Europe account for 46% and 29%.
In Nigeria, Africa’s most populous country, the government has recorded nearly 3,000 deaths so far among its 200 million population. The U.S. records that many deaths every two or three days.[4]
Why Some Viruses Can Be Good
Not all viruses are bad, and perhaps the Omicron variant could actually help us to overcome the pandemic. Omicron, like some viruses, can actually fight against more dangerous viruses and more dangerous COVID-19 variants such as the Delta variant. Keep in mind that viruses typically evolve to become less lethal over time. Like wolves domesticated into dogs, disease-causing viruses seem to become tamer in an effort to survive. The reasoning goes that, sooner or later, SARS-CoV-2 must “lose its fangs and become as boring as the common cold”.[5]
Generally, like protective bacteria (probiotics), we have several protective viruses in our body. I am a believer in hormesis and building adaptive response/immunity. For example, viral infections at a young age are important to ensure the proper development of our immune system. Yet, we keep believing we should vaccinate against everything that poses a threat, even if the threat is mild. We should vaccinate when we have a real threat, and we have proven, non-leaky, and safe vaccines. But this should still be a personal decision and based on a multitude of factors; such as the frail and elderly. Elderly individuals are the most susceptible to an aggressive form of COVID-19, caused by SARS-CoV-2.
In some cases, latent (non-symptomatic) herpes viruses can help human natural killer cells (a specific type of white blood cell) identify cancer cells and cells infected by other pathogenic viruses. They arm the natural killer cells with antigens (a foreign substance that can cause an immune response in the body) that will enable them to identify tumor cells.[6]
Researchers working in Uganda said they found COVID-19 patients with high rates of exposure to malaria were less likely to suffer severe disease or death than people with little history of the disease.
If the Omicron variant is truly as transmissible as the say and significantly less harmful – some reports say 1/10 as strong – should we be afraid of it?
The main part of my personal practice is supporting people with cancer, and there are many situations where approaching cancer with low-dose metronomic chemotherapy yields significantly better results than standard-of-care high dose chemotherapy. In Oncology, systemic chemotherapies typically use the maximum tolerated dose to cause maximum tumor cell death. However, this paradigm has been challenged, particularly in older people and those who have reoccurring cancer, by theoretical models of tumor evolution, which suggest that removal of all cells that are sensitive to chemotherapy permits unopposed proliferation of any remaining resistant cells — a phenomenon called ‘competitive release’. Competitive release applies to viruses and different mutations and occurs when one of two species competing for the same resource disappears, thereby allowing the remaining competitor to utilize the resource more fully than it could in the presence of the first species.
Based on this model, an evolution-based treatment strategy that maintains a residual population of chemotherapy-sensitive cells should suppress growth of resistant cells when therapy is withdrawn, as the drug-sensitive cells have a fitness advantage in this condition.
A 2016 study designed an evolution-based treatment strategy using taxol (paclitaxel) adaptive therapy (AT), and compared this with standard taxol therapy (ST) in orthotopic xenograft mouse models of triple-negative and estrogen receptor-positive breast cancer. Two AT regimens were tested: AT-1, which maintains dosing frequency, but decreases paclitaxel dose as a tumor responds, and AT-2, which uses the same doses of paclitaxel, but doses are skipped when a tumor has responded. The treatment algorithms relied on tumor volume measurements determined by magnetic resonance imaging (MRI), as this could be used clinically.
In both mouse models, ST initially suppressed tumor growth, but exponential growth resumed following treatment cessation. AT-1 had the same effect as ST initially but was able to maintain a stable tumor burden similar to the initial tumor volume throughout the experiment (∼2 months). This allowed continued reduction of the paclitaxel dose, and eventually treatment withdrawal in some cases. Interestingly, AT-2 controlled tumor volume for longer than ST, but unlike AT-1, tumors treated using AT-2 eventually progressed. A direct comparison between AT-1 and AT-2 indicated that AT-1 provided better tumor growth control.[7]
The failure to trigger an effective adaptive immune response in combination with a higher pro-inflammatory tonus may explain why the elderly do not appropriately control viral replication and the potential clinical consequences triggered by a cytokine storm, endothelial injury, and disseminated organ injury.[8]
Perhaps the best approach would be to implement strategies, such as herbal medicine and nutritional compounds, including Zinc, Vitamin D, Quercetin, Selenium and an immune health-promoting diet, which provides a diverse and robust GUT microbiota. This would be a sensible, cost-effective, approach that supports and optimizes innate health and the immune response.
Dysregulation of the gut microbiota (gut dysbiosis) is an important risk factor as the gut microbiota is associated with the development and maintenance of an effective immune system response.[9] The elderly have a significantly increased susceptibility to infections and it has been reported that probiotic bacteria from the genus bifidobacterium can enhance certain aspects of cellular immunity in the elderly.[10] The best places to find this beneficial bacterium are yogurt, probiotics like kefir, or sauerkraut.
Selenium is a trace mineral which is deficient in many people. It plays an important role in free radical scavenging, targeting oxidative damage, a major factor in the COVID-19 “cytokine storm,” which is the immune response with an overproduction of cytokines and other immune cells that can lead to a rapid multi-organ failure and damage to the lungs, heart and kidneys.[11] Animal studies show that selenium with ginseng stem/leaf saponins increase the immune response against infectious bronchitis causes by a live coronavirus vaccine.[12]
This may provide all those infected by SARS-CoV-2, to develop a milder disease and help them to clear the virus through an efficient adaptive immune response. With a milder form of COVID-19, being infected by the Omicron variant could be the path to building natural immunity which builds effective immune memory that can persist for decades and typically results in enhanced responses and accelerated pathogen control, and a generation of robust and durable T and B cell alike;[13] and this goes beyond the detection of antibodies. The absence of specific antibodies in the serum does not necessarily mean an absence of immune memory.[14]
Wishing a Joyous Christmas, Winter Solstice, belated Chanukah, and a Happy New Year to you and our world. May our prayers be our words in deeds, and may our earth be made very peaceful because of each of us.
[2] Lihong Liu, Sho Iketani, Yicheng Guo, Jasper Fuk Woo Chan, Maple Wang, Liyuan Liu, Yang Luo, Hin Chu, Yiming Huang, Manoj S. Nair, Jian Yu, Kenn Ka-Heng Chik, Terrence Tsz-Tai Yuen, Chaemin Yoon, Kelvin Kai-Wang To, Honglin Chen, Michael T. Yin, Magdalena E. Sobieszczyk, Yaoxing Huang, Harris H. Wang, Zizhang Sheng, Kwok-Yung Yuen, David D. Ho; Striking Antibody Evasion Manifested by the Omicron Variant of SARS-CoV-2, preprint doi: https://doi.org/10.1101/2021.12.14.472719
[3] Centers for Disease Control and Prevention, Glossary, Principles in Epidemiology in Public Health Practice, Third Edition, reviewed July 2, 2014, accessed December 17, 2021, https://www.cdc.gov/csels/dsepd/ss1978/glossary.html.
[11] Chen C, Zhang XR, Ju ZY, He WF. (2020). Advances In The Research Of Cytokine Storm Mechanism Induced By Corona Virus Disease 2019 And The Corresponding Immunotherapies. Zhonghua Shao Shang Za Shi (Chinese Journal of Burns), 36(0), E005. doi: 10.3760/cma.j.cn501120-20200224-00088. http://rs.yiigle.com/yufabiao/1183285.htm
Spices, herbal medicines, essential oils, and distilled natural products provide a rich source of compounds for the discovery and production of novel antiviral drugs. The determination of the antiviral mechanisms of these natural products has revealed how they interfere with the viral life cycle, i.e., during viral entry, replication, assembly, or discharge, as well as virus-specific host targets.[1]
A number of essential oils exhibit anti-viral and anti-influenza activities. These include Cinnamomum zeylanicum leaf oil (cinnamon), Citrus bergamia (bergamot), Cymbopogon flexuosus (lemongrass) and Thymus vulgaris (Red Thyme).[3] In studies, a blend of essential oils has been proven to inhibit the infectivity of influenza virus via inactivating viral binding ability and viral protein translation.[4]
Eucalyptus essential oil has been shown to improve the innate cell-mediated immune response and can be used as an immunoregulatory agent against infectious diseases.[5],[6]Tea tree oil and eucalyptus oil are capable of inactivating influenza virus A.[7] Geranium and lemon essential oils downregulate ACE2, a SARS-CoV-2 spike receptor-binding domain in epithelial cells, and are valuable natural anti-viral agents that may contribute to the prevention of the invasion of SARS-CoV-2 into the human body.[8]
Tea tree essential oil inhibits influenza during the early stages by preventing intracellular processing of the viral particle. When introduced into cell culture media, tea tree oil prevented viral uncoating by interfering with the acidification of the endosomes and membrane fusion. The ability to prevent endosome acidification was ascribed to the tea treeessential oil constituents terpinen-4-ol, α-terpineol and terpinolene. Tea treeessential oil, when actively diffused with a nebulizer for two seconds, cleared nearly all airborne influenza viruses at 10 minutes, and showed zero virus at 15 minutes post nebulizer treatment. Eucalyptus essential oil showed zero virus at 15 minutes following a 15 second period of active diffusion with a nebulizer.[9]
Lemon Balm (Melissa Officinalis) Leaves
Lemon balm (Melissa officinalis) essential oil has been used extensively to prevent HSV infection and to inhibit influenza viruses. Lemon balm essential oil has been shown to prevent attachment of the virus to host cell surface cell receptors.[10] Studies show that viral induced autophagy was effectively inhibited by clove bud (Eugenia caryophyllata) essential oil and eugenol in cells infected with 8 separate flu viruses. And a blend of clove bud and sweet orange (Citrus sinensis) essential oils has been shown to inhibit viral protein production.[11]
Essential oils are complex mixtures of compounds and several essential oil components may act synergistically to inhibit the virus.[12] For example, a study evaluated the in vitro antiviral effect against influenza type A (H1N1) of commercial essential oils that included cinnamon (Cinnamomum zeylanicum), bergamot (Citrus bergamia), lemongrass (Cymbopogon flexuosus), thyme (Thymus vulgaris), and lavender (Lavandula angustifolia). The oils were tested in the liquid phase at a concentration of 0.3% and in the vapor phase. The oils of cinnamon, bergamot, thyme, and lemongrass displayed 100% inhibition of H1N1 in the liquid phase, while the inhibition for lavender essential oil was 85%. However, in the vapor phase, 100% inhibition was observed only for cinnamon leaf essential oil after 30 min of exposure. The bergamot, lemongrass, thyme, and lavender essential oils displayed inhibition rates of 95%, 90%, 70%, and 80%, respectively.[13]
Limonene is a terpene compound found in many citrus oils. It may be a possible agent or adjuvant against infection, immunity, and inflammation in COVID-19.
There are a variety of ways to use essential oils. For optimal results, I recommend using a blend of oils. To use essential oils therapeutically:
Treat face masks by sprinkling a few drops onto the outer surface;
As an aerosol disinfectant or a surface sanitizing agent, combine 5% essential oil blend, 60% alcohol and 35% distilled water in a spray bottle;
Add essential oil to a diffuser;
Mix with a carrier oil and rub on hands and neck area. Use 5% EO blend to carrier oil (a blend of coconut and almond oil is very nice);
Add to a bath with Epsom salts and mustard powder (I like Dr. Singha’s Mustard Bath with essential oils). Use 1-2 cups of Epsom salts, 1 tablespoon mustard powder, 1 tablespoon of baking soda and 10-20 drops of essential oil blend. Taking this bath before bedtime with a diaphoretic tea blend is wonderful for helping with fevers, chills, and body aches.
Inhalation steam: Add 3-5 drops to a bowl of hot water, lean your head over the bowl, put a towel over your head and bowl, and breathe in the vapor.
Surgical masks are helpful for preventing virus spread into the air and transmission to humans. However, after mask removal, the virus remains on the mask and is probably re-aerosolized, increasing the risk of human infection. Coating the mask with a few drops of essential oil, or spraying the mask with an aerosol spray of essential oil blend as described above, may be helpful.
Lavender
Along with antiviral activity, there may be some relief of symptoms of COVID-19 provided by essential oils including relaxation and mood enhancement. For example, a systematic review and meta-analysis (65 RTCs) review paper on the effects of lavender essential oil found lavender to be very effective at reducing anxiety.[15]
There are nondrug therapeutic strategies targeting inflammatory and immunological processes that may be useful for reducing COVID-19-induced complications and improving patient outcome. For example, vagal nerve stimulation has a wide field of therapeutic benefit for patients and could easily be combined with the best current medical strategies. Vagus nerve stimulation attenuates inflammation both in experimental models and preliminary data in people. The development of non-invasive vagal nerve stimulation, a non-pharmacological adjuvant, may help reduce the burden of COVID-19 and could be investigated more thoroughly.[16] Continuous vagal tone monitoring in patients with COVID-19 could be used as a predictive marker of COVID-19 illness, as well as a predictive marker of response to COVID-19 treatment such as VNS or others.[17]
Activation of your vagus nerve counteracts your sympathetic nervous system. Stimulating the vagus nerve is a quick and easy way to relieve anxiety and is the “yin” activator that can reduce heart rate and blood pressure and stimulate digestion.
The vagus nerve functions in the service of awakening (sub or super) consciousness and in immortality – the connection to Spirit. This system is described in the Tibetan Inner Fire meditations as well as in the Taoist, “shen” breathing practices.[18]
When you stimulate your vagus nerve, it releases an array of anti-stress enzymes and hormones such as acetylcholine, prolactin, vasopressin, and oxytocin. Vagus nerve stimulation is associated with benefits such as improved memory, immune function, sleep, and higher levels of growth hormone. It can also help to regulate immune function – buffering inflammation, allergic responses, and even tension headaches. Increased positive social connections are also beneficial for your overall wellbeing. Positive emotions, positive social connections, and physical health influence one another in a self-sustaining upward-spiral dynamic.[19]
Repetitive meditation or prayer, often with beads or knotted ropes, and controlled deep breathing are other relaxation technique that can have health benefits.
In these challenging times, when we’re constantly confronted with uncertainty, one of the most beneficial things we can do for our emotional and physical wellbeing is to practice being present, calm, and grateful. I recommend preparing a relaxing candlelight bath with lavender essential oil and reading and reflecting on something you find spiritually nourishing to relieve stress and lift the spirits.
[18]Brown D., The energy body and its functions: immunosurveillance, longevity, and regeneration, Ann N Y Acad Sci. 2009 Aug;1172:312-37. doi: 10.1196/annals.1393.019.
When it comes to the question of vaccine immunity verses natural immunity, the stance taken by the CDC is that vaccine immunity is stronger, which they maintain is confirmed by research. But when you analyze the study they use and compare it to, for example, the Israeli study that states the opposite, there is an enormous discrepancy. And this discrepancy is between studies that are designed to answer the same question.
The Israeli study[1] found that the vaccinated have a 27 times higher risk of symptomatic infection than those who recovered from Covid-19 infection. At the same time, the vaccinated were nine times more likely to be hospitalized for Covid. In contrast, a CDC study[2] by Bozio et al. claims that the Covid recovered are five times more likely to be hospitalized for Covid than the vaccinated. Both studies cannot be right.
While a recent Centers for Disease Control and Prevention (CDC) report released findings that alleged recovered individuals have a 5.5 times more likely chance of being hospitalized when compared to vaccinated people with no prior infection, no other independent research corroborates these findings.
This CDC report was recently dismantled by Harvard epidemiologist Dr. Martin Kulldorf and was revealed to have fatal flaws.[3] He states that the Israeli study was a “straightforward and well-conducted epidemiological cohort study that is easy to understand and interpret.” At the same time, he found the US study filled with flaws, deeming it fatally flawed. He goes on to say, “It is surprising that the CDC chose this case-control design rather than the less biased cohort design selected by the Israeli authors. Such an analysis would answer the question of interest and may have given a different result more in line with the Israeli study.”
A very recent December 4th, 2021, study[4] supported the finding of the Israeli study, in that infected individuals with or without one vaccination dose have better protection than uninfected doubly-vaccinated individuals 3 to 8 months after the last immunity-conferring event. The data from this study does not suggests that vaccinated individuals were more protected than previously infected individuals 3 to 6 months after the immunity-conferring event. This study highlights that hybrid immunity is the strongest immunity. In other words, those that have been both infected and have received at least one dose of the vaccine.
How the Omicron Variant Differs
Other variants including Alpha, Beta, Gamma, and Delta have had maybe eight or 10 mutations in the spike protein, and that’s largely what’s given them their advantageous phenotype. Omicron originated with 30 or more mutations in the spike protein!
There has been rapid spread in South Africa’s Gauteng province of Omicron as it rapidly replaces Delta. Omicron is spreading almost three times faster when compared to the Delta variant, which was two times faster compared to previous variants.
Early Lab Data Provide Glimpse into Omicron’s Immune Escape
Preliminary data from a small study at a prominent South African lab have found a 41-fold reduction in neutralizing antibody titers for the Pfizer vaccine against Omicron.
Omicron was first identified on 23 November in South Africa by researchers using genome sequencing to investigate a puzzling surge in case numbers there. Daily cases went from 274 on 11 November to 1000 a fortnight later, and currently number more than 2000.
Stéphane Bancel, chief executive of Covid-19 vaccine maker Moderna, has predicted that omicron will cut the efficacy of existing vaccines. The new variant is also expected to be more resistant to antibody treatments such as those developed by Regeneron. “That is really a cause for concern,” says Barclay.[6]
Most experts now propose Omicron most likely developed in a chronically infected Covid-19 patient, likely someone whose immune response was impaired by another illness or a drug. When Alpha was first discovered in late 2020, that variant also appeared to have acquired numerous mutations all at once, leading researchers to postulate a chronic infection. The idea is bolstered by sequencing of SARS-CoV-2 samples from some chronically infected patients.[7]
Cancer Patients May Have Double the Risk of Breakthrough Infection After Covid-19 Vaccination
Most patients with solid tumors develop antibodies after Covid-19 vaccination, but many patients with hematologic malignancies fail to seroconvert, according to a meta-analysis published in the European Journal of Cancer.[8] Studies have shown that a “substantial proportion” of blood cancer patients who did not produce anti-S antibodies following complete vaccination continue to be seronegative after receiving an additional dose.[9]
The fact that some patients have poor immune responses even after 3 vaccine doses highlights the importance of additional precautions to prevent SARS-CoV-2 infection, according to Dr Vaca- Cartagena.[10] However, it does appear for the time being that vaccine boosters provide protection to cancer patients. The meta-analysis did not include data on seroconversion rates in cancer patients after a booster dose of a Covid-19 vaccine.[11] Since the researchers conducted the meta-analysis, studies have come out suggesting that additional vaccine doses may benefit patients with cancer.[12],[13]
Viral resistance can drive enhanced infectiousness of SARS-CoV-2, which in turn may ultimately enable SARS-CoV-2 to utilize alternative cell surface determinants to enter permissive cells. It is plausible that mass vaccination may drive the virus to fully exploit its evolutionary capacity, including its ability to use alternate receptor domains other than the Spike protein. This can lead to enhanced pathogenicity.[14] This is not an anti-vax statement, but rather an insight into the importance of supporting our innate healing capacity.
Viruses continually mutate, and by relying solely on vaccines, we are engaging in a never-ending race to stay ahead of the mutations. Supporting our overall health and innate immune response capacity is not variant specific and is a prudent approach to Covid-19, particularly as it becomes more apparent that there will never be a “post-Covid” world. We need to understand and accept that Covid-19 is here to stay. We need strategies beyond vaccines alone for living with this virus, starting with building our own robust health and immunity and reducing known risk factors where possible.
There are volumes of existing irrefutable evidence that foods, herbs and specific nutrients possess potential antiviral immune enhancing ability against SARS-CoV-2. According to recent research, herbal medicines, like herbs and essential oils, may have a part to play in counteracting Covid-19.[15] As we head into the 3rd year of living with Covid-19, there is no doubt in my mind we would be in a very different situation today if we had embraced dietary, herbal, and nutritional medicine for supportive care during the past two years, but it’s not too late to start. In my next blog, I’ll be sharing all the wonderful antiviral properties of some of my favorite essential oils.
[1] Sivan Gazit, Roei Shlezinger, Galit Perez, Roni Lotan, Asaf Peretz, Amir Ben-Tov, Dani Cohen, Khitam Muhsen, Gabriel Chodick, Tal Patalon, Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections
doi: https://doi.org/10.1101/2021.08.24.21262415
[2] Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021, Weekly / November 5, 2021 / 70(44);1539–1544, On October 29, 2021, this report was posted online as an MMWR Early Release.https://www.cdc.gov/mmwr/volumes/70/wr/mm7044e1.htm
[4] Yair Goldberg, Micha Mandel, Yinon M. Bar-On, Omri Bodenheimer, Laurence Freedman, Nachman Ash, Sharon Alroy-Preis, Amit Huppert, Ron Milo, Protection and waning of natural and hybrid COVID-19 immunity, MedRxiv, BMJJ Yale, doi: https://doi.org/10.1101/2021.12.04.21267114
[5]Kristina Fiore, Early Lab Data Provide Glimpse Into Omicron’s Immune Escape, MedPage Today December 8, 2021,
[6] Vaughan, Adam, Omicron emerges, 4 December 2021 | New Scientist | 7, Mutations could have accumulated in a chronically infected patient, an overlooked human population, or an animal reservoir
[9] Re D, Seitz-Polski B, Carles M, et al. Humoral and cellular responses after a third dose of BNT162b2 vaccine in patients treated for lymphoid malignancies. medRxiv. Published online July 22, 2021. doi:https://doi.org/10.1101/2021.07.18.21260669
[15] Vellingiri B., Jayaramayya K., Iyer M., Narayanasamy A., Govindasamy V., Giridharan B., Rajagopalan K. COVID-19: A promising cure for the global panic. Sci. Total. Environ. 2020:138277. doi: 10.1016/j.scitotenv.2020.138277.
“We need to make the kind of society where it is easier for people to be good.”
Peter Maurin (1877–1949)
Many of us are looking forward to once again gathering with friends and family at Thanksgiving. Along with enjoying our favorite delicious holiday foods and other traditions, let’s remember that the heart of Thanksgiving is gratitude. In the midst of the crucible of change that the world is experiencing, we need to focus our attention and efforts on loving each other more, and doing what we can to make the world a better place for everyone.
I offer this simple Thanksgiving prayer of reflection: “May I trust my own goodness. May I see the goodness in others. May we always remain hopeful and live in the present with gratitude and love in our hearts.”
“Hope says God has not abandoned us in the world … He pursues us, dwells in us, intervenes for us and will not forget us.” Scott McClellian[1]
Apples: A Traditional Harvest Food
Celebrating the bounty of the harvest is one of the joys of Thanksgiving. Apples are among
my favorite fall foods, and the humble fruit has a wide array of health benefits. There’s a lot of truth in the saying, “An apple a day keeps the doctor away.”
Apples are a good source of nutrients, including minerals, dietary fiber, antioxidants, and ursolic acid. Preclinical studies have found apple pomace and its isolated extracts improve lipid metabolism, antioxidant status, and gastrointestinal function and demonstrate a positive effect on metabolic disorders (eg, hyperglycemia, insulin resistance, etc.).[2]
Epidemiological studies show that frequent apple consumption is associated with a reduced risk of cardiovascular disease, and that apples are an ideal food for cholesterol management.[3],[4],[5]Consumption of apples and the individual flavonoid compounds, quercetin and epicatechin are associated with a lower risk of all-cause mortality.[6]
Apples contain over one hundred phenolic compounds with antioxidant and anti-inflammatory effects.These phenolic acids and flavonoids comprise six major classes: phenolcarboxylic acids (e.g., chlorogenic acid), anthocyanins (e.g., cyanidin glycosides), flavonols (e.g., quercetin glycosides), dihydrochalcones (e.g., phloridzin), flavan-3-ols (e.g., catechin), and procyanidins (e.g., procyanidin B2).[7]
Synergy is the Key
The key to the health benefits of apples is the combination of active compounds, known as the synergistic effect. A major proportion of the bioactive components in apples, including high molecular weight polyphenols, are converted by the colonic microbiota to bioavailable and biologically active compounds with systemic health benefits, in addition to modulating microbial composition.[8]
Apples have been found to inhibit chronic disease, including cancer cell proliferation[9],[10],[11],[12]and tumors.[13],[14]
In studies, fresh Red Delicious apple extract inhibited cell proliferation in a dose-dependent manner in colon cancer. Apple extract also inhibited human liver tumor cells. Researchers found that tumor proliferation was inhibited 57% by extract containing apple skin and 40% by extract not containing skin.[15]
Apples inhibit tyrosinase and possess anti-melanoma effects in B16 mouse melanoma cells, as well.[16]
For those trying to lose excess weight, I highly recommend eating an apple before a meal. Apples are low in calories, highly nutritious, and help you to feel satisfied and less hungry. There are other health benefits to eating an apple daily, as well. A recent study found that whole Gala apple consumption is an effective dietary strategy to mitigate high fat meal-induced postprandial inflammation that exacerbates cardiovascular disease risk in overweight and obesity.[17] And another recent study showed the replacement of calories in the Western diet with apple pomace attenuated non-alcoholic fatty liver disease risk.[18]
Have a blessed Thanksgiving!
“I am not this hair, I am not this skin, I am the soul that lives within.” ~ Rumi
Do you know how New York City got the nickname “The Big Apple”?
Although New York State is America’s top apple grower, after the state of Washington, the New York City nickname has nothing to do with fruit production. The Big Apple moniker first gained popularity in connection with horseracing. Around 1920, New York City newspaper reporter John Fitz Gerald, whose beat was the track, heard African-American stable hands in New Orleans say they were going to “the big apple,” a reference to New York City, whose race tracks were considered big-time venues. Fitz Gerald soon began making mention of the Big Apple in his newspaper columns. In the 1930s, jazz musicians adopted the term to indicate New York City was home to big-league jazz clubs.[19]
Since Thanksgiving is “as American as apple pie” I thought I might throw you a curve ball and present an Upside Down Apple Cake recipe as an alternative. https://www.donnieyance.com/upside-down-apple-cake/
